Buy Sorafenib (Nexavar) tablets online
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Indications and usage:
Nexavar (Sorafenib Tosylate) is a kinase inhibitor indicated for the treatment of:
Unresectable hepatocellular carcinoma
Advanced renal cell carcinoma
Locally recurrent or metastatic, progressive, differentiated thyroid carcinoma refractory to radioactive iodine treatment
Dosage and administration:
400 mg (2 tablets) orally twice daily without food.
Treatment interruption and/or dose reduction may be needed to manage adverse reactions.
There is no specific treatment for sorafenib overdose. The highest dose of Nexavar studied clinically is 800 mg twice daily. The adverse reactions observed at this dose were primarily diarrhea and dermatologic. No information is available on symptoms of acute overdose in animals because of the saturation of absorption in oral acute toxicity studies conducted in animals. In cases of suspected overdose, sorafenib should be withheld and supportive care instituted.
Dosage forms and strengths:
Nexavar (Sorafenib Tosylate) 200 mg oral tablets.
Sorafenib is contraindicated in patients with known severe hypersensitivity to sorafenib or any other component of Nexavar.
This drug in combination with carboplatin and paclitaxel is contraindicated in patients with squamous cell lung cancer.
Warnings and precautions:
Cardiovascular Events: Consider temporary or permanent discontinuation of Nexavar.
Bleeding: Discontinue Nexavar if needed.
Hypertension: Monitor blood pressure weekly during the first 6 weeks and periodically thereafter.
Dermatologic Toxicities: Interrupt and/or decrease dose. Discontinue for severe or persistent reactions, or if Stevens-Johnson syndrome and toxic epidermal necrolysis is suspected.
Gastrointestinal Perforation: Discontinue Nexavar.
QT Prolongation: Monitor electrocardiograms and electrolytes inpatients at increased risk for ventricular arrhythmias.
Drug-Induced Liver Injury: Monitor liver function tests regularly; discontinue for unexplained transaminase elevations.
Embryo-Fetal Toxicity: Sorafenib may cause fetal harm. Advise patients of the potential risk to a fetus and to use effective contraception.
Impairment of TSH suppression in DTC: Monitor TSH monthly and adjust thyroid replacement therapy in patients with thyroid cancer.
Adverse reactions, side effects:
The most common adverse reactions ( >= 20%) for Nexavar tablets are diarrhea, fatigue, infection, alopecia, hand-foot skin reaction, rash, weight loss, decreased appetite, nausea, gastrointestinal and abdominal pains, hypertension, and hemorrhage.
Avoid strong CYP3A4 inducers.
Use in specific populations:
Lactation: Advise women not to breastfeed.
Females and Males of Reproductive Potential: Verify pregnancy status prior to initiation of Nexavar (Sorafenib Tosylate) 200 mg tablets,
Where to buy sorafenib online:
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